NEW! Test your medical knowledge each month with questions from The Medical Knowledge Self-Assessment Program庐 (MKSAP).
MKSAP has been trusted by internists since 1967 as the best resource for updating knowledge. MKSAP 18, available in Complete, Digital, and Print packages, consists of 11 comprehensive text chapters with related multiple-choice questions. You'll find 1,200 completely new questions to help you identify learning gaps, stay current, and gain the knowledge you need to provide the best possible patient care. MKSAP 18's original and high-quality questions evolve out of case studies and patient scenarios based on the latest evidence.
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MKSAP 18 Q & A
A 26-year-old woman is interested in genetic testing for BRCA1 and BRCA2 gene mutations based on her family history. Her mother was diagnosed with triple-negative breast cancer at age 53 years and died at age 55 years. Her maternal aunt was diagnosed with ovarian cancer at age 48 years and is still alive but is not interested in genetic testing. Her maternal and paternal relatives are of Ashkenazi Jewish descent. The patient is premenopausal and takes no medications.
On physical examination, vital signs are normal. Breast and gynecologic examination findings are normal.
Which of the following is the most appropriate management?
A: Recommend a direct-to-consumer genetic test
B: Recommend against genetic testing
C: Recommend genetic testing for the three BRCA1 and BRCA2 mutations most common in patients of Ashkenazi Jewish ethnicity
D: Refer to a genetic counselor