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Measuring patient response to major depressive disorder (MDD) is incredibly important as they progress toward remission. The performance measure aims to assess a patient’s progress toward remission by achieving a response within the time interval. It is important to consider the severity of the initial MDD screening, as some interventions will take longer to take effect in populations with more resistant MDD. The index period for the denominator is well-defined; it measures patients who have an index visit within the set calendar period (e.g., dates between November 1 and October 31) and allows enough time to pass to accommodate the timeframe for assessment (+/- 60 days of the index date of service). The collection burden for this performance measure is moderate and physician control is low.